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The boy – Fletcher – discovered soon enough how boundlessly and profoundly life-affecting the afternoon would prove to be. His afternoon intersected with that of Preston, who was in an ambulance on his way to St Luke's hospital to be treated for burns when a 12-year-old was bundled aboard, concerned only at the moment to know "how did Leeds United get on" that day. That certainly changed when Martin Fletcher told his story. So do the sounds of some of those 150 people present, packing the little theatre's benches to capacity, needing to leave the dark space and take a moment to recover themselves. The unheroic obstinacy of the woman who refused to leave without her handbag "because my teeth are in it." Some laughs puncture the rapt silence of the 75 minutes at Bradford's Alhambra theatre studio. And so, too, is the black tragicomedy which can exist at the boundaries. The men with no hair feeling the searing pain first supporters entering hospital with their hands melted to their heads by the asphalt which has leaked from the stadium roof a fan's trilby hat igniting. The scriptwriters' hours of interviews with those caught up in the horror are distilled into the narratives of three survivors, and the casual horrors of what befell football supporters that day are all in there. The play, entitled simply The 56, does not seek to make melodrama out of that 11 May afternoon at Valley Parade, when fans arrived to celebrate Bradford's promotion from the Football League's division 3. And so it has been that while Liverpool supporters' refusal to accept the received narrative of Hillsborough – the stadium disaster 40 miles north across Yorkshire in which 96 died – has made it a source of anger and liberation at the heart of the national consciousness, Bradford became the forgotten tragedy. The play reflects that it had been "the Yorkshire way" not to make a fuss, to bear a loss and move on. This is the kind of understated remembrance we have seen in Bradford these past few months, at the onset of another significant anniversary of the 1985 fire which tore across the local football club's old wooden main stand, reducing it to a collapsing inferno in a mere four minutes and claiming 56 lives. ![]() ![]() The children were still nestled under the warden's thick overcoat when they discovered them. ![]() He and the children all perished, along with the boys' father. She was Hazel Greenwood – the mother whose children, 13-year-old Felix and 11-year-old Rupert, had been ushered away from the flames of the stadium fire all those years ago by a traffic warden, seeking to shelter them under his tunic. And only after she had gone – vanished into the kind of warm Bradford Saturday night on which wives, children, parents and friends first learned that they were the bereaved, 30 years ago next week – did the significance of her gratitude become clear. Thank you for telling this," said the woman, who was perhaps 60 or so, to one of the young people whose stage play, based on football's Bradford disaster, had just concluded on the small theatre space behind her. ![]() Finish off your masterpiece with the border color that catches your eye, or select from 10 border designs. Versatile collage feature gives you a ton of flexibility to create and customize! Select from over 100 templates up to 9 photos at a time, or use Free Style to move photos around whatever you want with 26 unique backgrounds to choose from. Batch processing can help apply Scenes, Effects, and Borders with one click, and can also quickly complete Batch resizing, renaming, and file format conversion. 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Design function with over 100,000 design resource elements and millions of HD licensed images for personal and commercial use HDR photography for more detailed and high-quality color images Versatile collage feature with over 100 templates and 26 unique backgrounds to choose from Batch processing for quick editing of multiple photos Portraits touch-up function for smoothing skin, reshaping faces, and enhancing lifelike appearance Save editing operations as "recipes" for future use Flexible text editing tool with options to adjust font, size, and color Adjust exposure, brightness, contrast, white balance, saturation, sharpen/blur, highlights/shadows, HSL, add a vignette or film grain, remove red eye, reduce image noise, crop, straighten, rotate, fix image distortion or correct lens distortion State-of-the-art photo processing engine for high-quality photo editing ![]() Anyways its just my opinion on the matter, I will still play it because I enjoy glassfish work but I would hope people dont get bored of update after update just pumping out (insert girl name here) content like "SuperPowered". Have his mom be one of the crew, have a rival, have his sister be his rival, have a daughter, idk something like that. "You play as John Doe, seducing then fucking your crew members, some will hate you some will love you." Wheres the "umph", the fire, the kick. Personally I just think a sci-fi harem or how most would see it, a harem in a sci-fi setting is just stale on its own. The most common one I have found has been incest being used to spice up a story and character dynamic. ![]() ![]() Most popular games or in other words games that become popular I have noticed tend to have something that pushes it out of the traditional norm. As well as incest and other weird shit so it can be put off the "vanilla/generic" list I would think. Again it would be a case of quantity vs quality, if Seeds of Chaos was all about Rowan being a Chad slaying pussy im sure that the game would have easily reached 20k or so long ago.Ĭlick to expand.Seeds of Chaos if I recall has NTR themes in it. But really the issue is that these games must give content periodically and so if the game lacks focus it wont appeal to anyone if they have to wait several updates waiting for their fetishes to shime in. I mean even though Seeds of Chaos has one of the best devs regarding work ethics and being one of the original wegs, It had the slowest growth out of all of its peers and that game has nearly every fetish imaginable which would had given it bigger support if the theory of many fetishes giving it more support held true. Well think of the most popular games: SS, FET, Milfy City, Monster Girl Island, etc which are harem and really they dont push the envelope fetish wise (Well I guess Eve being a trap is one which was quite controversial and it was added until this late in the game when it had already built its fanbase through tame content) so really a bunch of fetishes wont really factor. Not to mention that the artist is relatively popular so I think this game has enough appeal to succeed but it will also need a good release schedule. Still I think that being a harem sci fi game gives it a niche. Again it would be a case of quantity vs quality, if Seeds of Chaos was all about Rowan being a Chad slaying pussy im sure that the game would have easily reached 20k or so long ago. ![]() Click to expand.Well think of the most popular games: SS, FET, Milfy City, Monster Girl Island, etc which are harem and really they dont push the envelope fetish wise (Well I guess Eve being a trap is one which was quite controversial and it was added until this late in the game when it had already built its fanbase through tame content) so really a bunch of fetishes wont really factor. ![]() Although most compounds that are positive in this test are mammalian carcinogens, the correlation is not absolute it varies with chemical class.Nevertheless, it is still important to perform the bacterial reverse mutation test. under "Modifications of Test Battery," in IV.C.1.). For these cases, usually two in vitro mammalian cell tests should be performed using two different cell types and two different endpoints, i.e., gene mutation and chromosomal damage (as discussed in section a. This may be the case for compounds that are excessively toxic to bacteria ( e.g., some antibiotics) and compounds thought or known to interfere with the mammalian cell replication system ( e.g., topoisomerase inhibitors, nucleoside analogues, or inhibitors of DNA metabolism). There are circumstances in which the bacterial reverse mutation test may not provide sufficient information for the assessment of genotoxicity.There are examples of mutagenic agents which are not detected by this test reasons for this shortcoming can be ascribed to the specific nature of the endpoint detected, differences in metabolic activation, or differences in bioavailability. ![]() An extensive data base has demonstrated that many chemicals that are positive in this test also are genotoxic in other tests. The bacterial reverse mutation test is commonly employed as an initial screen for genotoxic activity and, in particular, for point mutation-inducing activity.The test therefore does not provide direct information on the mutagenic and carcinogenic potency of a substance in mammals. In vitro metabolic activation systems cannot mimic entirely the mammalian in vivo conditions. Tests conducted in vitro generally require the use of an exogenous source of metabolic activation. The bacterial reverse mutation test utilizes prokaryotic cells, which differ from mammalian cells in such factors as uptake, metabolism, chromosome structure and DNA repair processes.In a reversion test this change may occur at the site of the original mutation, or at a second site in the bacterial genome.įrameshift mutagens are agents that cause the addition or deletion of one or more base pairs in the DNA, thus changing the reading frame in the RNA. Point mutations may result from base pair substitutions or from small insertions or deletions.īase pair substitution mutagens are agents that cause a base change in DNA. Point mutations are changes in one or a small number of base pairs in a DNA sequence. Reverse mutation test in either Salmonella typhimurium or Escherichia coli detects mutation in an amino acid requiring strain (histidine or tryptophan, respectively) to produce a strain whose growth is independent of an outside supply of the amino acid. A very large data base of results for a wide variety of chemical structures is available for bacterial reverse mutation tests and well-established procedures have been developed for testing chemicals with different physicochemical properties, including volatile compounds. The specificity of the tester strains can provide some useful information on the types of mutations that are induced by genotoxic agents. Many of the tester strains have several features that make them more sensitive for the detection of mutations, including responsive DNA sequences at the reversion sites, increased cell permeability to large molecules and elimination of DNA repair systems or enhancement of error-prone DNA repair processes. The bacterial reverse mutation test is rapid, inexpensive and relatively easy to perform. Point mutations are the cause of many human genetic diseases and there is substantial evidence that point mutations in oncogenes and tumor suppressor genes of somatic cells are involved in tumor formation in humans and experimental animals.The revertant bacteria are detected by their ability to grow in the absence of the amino acid required by the parent tester strain. (3), (9), (16) The principle of this bacterial reverse mutation test is that it detects chemicals that induce mutations which revert mutations present in the tester strains and restore the functional capability of the bacteria to synthesize an essential amino acid. coli) to detect point mutations, which involve substitution, addition or deletion of one or a few DNA base pairs. The bacterial reverse mutation test uses amino acid-requiring strains of Salmonella typhimurium ( S.If you cannot identify the appropriate FDA staff, call the appropriate number listed on the title page of this guidance. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. This guidance represents the Food and Drug Administration's (FDA's) current thinking on this topic. |